Mechanistic insight into the epigenomic reprogramming in iAs-mediated carcinogenesis

At the one-dimensional (1D) level, chromatin is found as nucleosomes and at the three dimensional level (3D), chromatin is found in loops and topological domains, both of which regulate gene expression by allowing accessibility to the DNA wrapped up as chromatin. Inorganic arsenic (iAs) is a ubiquitous metal that impacts gene regulation through modulating the epigenome. We recently provided the epigenetic landscape mediated by iAs. We are now teasing how iAs by directly dysregulating the binding of CTCF (the 'master weaver' of the genome) results in oncogenic 3D rewiring of the genome.

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